Please use this identifier to cite or link to this item: https://cris.pasteurorg.ru/handle/123456789/150
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dc.contributor.authorMorkovnik, Anatolii Sen_US
dc.contributor.authorDivaeva, Liudmila Nen_US
dc.contributor.authorKarpinskaya, Liubov' Aen_US
dc.contributor.authorBorodkin, Gennadii Sen_US
dc.contributor.authorZarubaev, Vladimir V.en_US
dc.date.accessioned2019-05-13T13:33:44Z-
dc.date.available2019-05-13T13:33:44Z-
dc.date.issued2016-
dc.identifier.issn0968-0896en_US
dc.identifier.urihttps://cris.pasteurorg.ru/handle/123456789/150-
dc.description.abstractA series of 1,3-disubstituted 2-iminobenzimidazolines as well as a number of their tautomeric analogs were synthesized. The synthesized compounds were tested for their cytotoxicity against MDCK cells and for inhibiting activity against influenza virus A/California/07/09 (H1N1)pdm09. Based on the results obtained, 50% cytotoxic concentration (CC50), 50% inhibiting concentration (IC50) and selectivity index (SI) were calculated for each compound. It was found that some of synthesized benzimidazole derivatives (7 of 22, 32%) possess strong virus-inhibiting activity against pandemic influenza virus (IC50's in low micromolar range) with quite moderate cytotoxicity (CC50 in the range of thousands micromoles). Due to their high selectivity (highest SI's=50-83) these compounds are of significant interest for further in vivo experiments as well as for further structural optimization and drug development.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofBioorganic and Medicinal Chemistryen_US
dc.subject2-Acylaminobenzimidazolesen_US
dc.subject2-Iminobenzimidazolinesen_US
dc.subject2-Thioureidobenzimidazolesen_US
dc.subjectAntiviral activityen_US
dc.subjectCytotoxicityen_US
dc.subjectInfluenza virusen_US
dc.titleTautomeric and non-tautomeric N-substituted 2-iminobenzimidazolines as new lead compounds for the design of anti-influenza drugs: An in vitro studyen_US
dc.typeJournal Articleen_US
dc.identifier.doi10.1016/j.bmc.2016.09.036-
dc.identifier.pmid27670100-
dc.identifier.urlhttps://europepmc.org/abstract/MED/27670100-
dcunis.statusPlanplanen_US
dc.typepublishingrusen_US
dc.identifier.eissn1464-3391-
dc.identifier.volume24en_US
dc.identifier.issue22en_US
dc.identifier.spage5796-5803en_US
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