Please use this identifier to cite or link to this item: https://cris.pasteurorg.ru/handle/123456789/151
Title: Anti-influenza activity of monoterpene-derived substituted hexahydro-2H-chromenes
Authors: Patrusheva, Oksana S
Shtro, Anna A
Orshanskaya, Yana R
Boldyrev, Sergey A
Ilyina, Irina V
Kurbakova, Svetlana Yu
Korchagina, Dina V
Volcho, Konstantin P
Salakhutdinov, Nariman F
Zarubaev, Vladimir V. 
Keywords: Antiviral;Chromene;Influenza;Monoterpene
Issue Date: 2016
Publisher: Elsevier
Journal: Bioorganic and Medicinal Chemistry 
Abstract: The antiviral activity of 4-hydroxy-hexahydro-2H-chromenes and 4-fluorine-hexahydro-2H-chromenes with an aromatic substituent, synthesized from monoterpene (-)-verbenone, was studied for the first time. Five of 11 (45 per cent) of 4-hydroxy-hexahydro-2H-chromene-type compounds have been found to exhibit antiviral activity against influenza A virus of subtype H1N1pdm09. Although a portion of active compounds among 4-fluorine-containing series was fewer, just compound 5i that contains a fluorine substituent exhibited more potent anti-influenza activity along with low cytotoxicity. Thus two new promising types of antiviral compounds were identified.
URI: https://cris.pasteurorg.ru/handle/123456789/151
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2016.08.037
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