Please use this identifier to cite or link to this item:
Title: Discovery of a new class of antiviral compounds: camphor imine derivatives
Authors: Sokolova, Anastasiya S
Yarovaya, Olga I
Shernyukov, Andrey V
Gatilov, Yuriy V
Razumova, Yuliya V
Tretiak, Tatiana S
Pokrovsky, Andrey G
Kiselev, Oleg I
Salakhutdinov, Nariman F
Zarubaev, Vladimir V. 
Keywords: Antiviral;Cage compounds;Camphor derivatives;Influenza
Issue Date: 13-Nov-2015
Publisher: Elsevier
Journal: European Journal of Medicinal Chemistry 
Abstract: A new class of compounds featuring a camphor moiety has been discovered that exhibits potent inhibitory activity against influenza A(H1N1)pdm09 and A(H5N1) viruses. The synthesized compounds were characterized by spectroscopic analysis; in addition the structures of compound 2 and 14 were elucidated by the X-ray diffraction technique. Structure-activity relationship studies have been conducted to identify the 1,7,7-trimethylbicyclo[2.2.1]heptanes2-ylidene group as the key functional group responsible for the observed antiviral activity. The most potent antiviral compound is imine 2 with therapeutic index more than 500.
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2015.10.010
Appears in Collections:Journal articles

Show full item record


checked on May 14, 2019

Page view(s)

checked on May 20, 2019

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.