Please use this identifier to cite or link to this item: https://cris.pasteurorg.ru/handle/123456789/154
Title: Discovery of a new class of antiviral compounds: camphor imine derivatives
Authors: Sokolova, Anastasiya S
Yarovaya, Olga I
Shernyukov, Andrey V
Gatilov, Yuriy V
Razumova, Yuliya V
Tretiak, Tatiana S
Pokrovsky, Andrey G
Kiselev, Oleg I
Salakhutdinov, Nariman F
Zarubaev, Vladimir V. 
Keywords: Antiviral;Cage compounds;Camphor derivatives;Influenza
Issue Date: 13-Nov-2015
Publisher: Elsevier
Journal: European Journal of Medicinal Chemistry 
Abstract: A new class of compounds featuring a camphor moiety has been discovered that exhibits potent inhibitory activity against influenza A(H1N1)pdm09 and A(H5N1) viruses. The synthesized compounds were characterized by spectroscopic analysis; in addition the structures of compound 2 and 14 were elucidated by the X-ray diffraction technique. Structure-activity relationship studies have been conducted to identify the 1,7,7-trimethylbicyclo[2.2.1]heptanes2-ylidene group as the key functional group responsible for the observed antiviral activity. The most potent antiviral compound is imine 2 with therapeutic index more than 500.
URI: https://cris.pasteurorg.ru/handle/123456789/154
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2015.10.010
Appears in Collections:Journal articles

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