Please use this identifier to cite or link to this item: https://cris.pasteurorg.ru/handle/123456789/157
Title: Glycyrrhizic acid derivatives as influenza A/H1N1 virus inhibitors
Authors: Baltina, Lidia A
Baltina, Lia A
Orshanskaya, Iana A
Fairushina, Alina I
Kiselev, Oleg I
Yunusov, Marat S
Zarubaev, Vladimir V. 
Keywords: Analogs;Antivirals;Derivatives;Glycyrrhizic acid;Influenza A/H1N1 virus
Issue Date: 15-Apr-2015
Publisher: Elsevier
Journal: Bioorganic and Medicinal Chemistry Letters 
Abstract: This Letter describes the synthesis and antiviral activity study of some glycyrrhizic acid (GL) derivatives against influenza A/H1N1/pdm09 virus in MDCK cells. Conjugation of GL with l-amino acids or their methyl esters, and amino sugar (d-galactose amine) dramatically changed its activity. The most active compounds were GL conjugates with aromatic amino acids methyl esters (phenylalanine and tyrosine) (SI=61 and 38), and S-benzyl-cysteine (SI=71). Thus modification of GL is a perspective route in the search of new antivirals, and some of GL derivatives are potent as anti-influenza A/H1N1 agents.
URI: https://cris.pasteurorg.ru/handle/123456789/157
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2015.02.074
Appears in Collections:Journal articles

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