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|Title:||Glycyrrhizic acid derivatives as influenza A/H1N1 virus inhibitors||Authors:||Baltina, Lidia A
Baltina, Lia A
Orshanskaya, Iana A
Fairushina, Alina I
Kiselev, Oleg I
Yunusov, Marat S
Zarubaev, Vladimir V.
|Keywords:||Analogs;Antivirals;Derivatives;Glycyrrhizic acid;Influenza A/H1N1 virus||Issue Date:||15-Apr-2015||Publisher:||Elsevier||Journal:||Bioorganic and Medicinal Chemistry Letters||Abstract:||This Letter describes the synthesis and antiviral activity study of some glycyrrhizic acid (GL) derivatives against influenza A/H1N1/pdm09 virus in MDCK cells. Conjugation of GL with l-amino acids or their methyl esters, and amino sugar (d-galactose amine) dramatically changed its activity. The most active compounds were GL conjugates with aromatic amino acids methyl esters (phenylalanine and tyrosine) (SI=61 and 38), and S-benzyl-cysteine (SI=71). Thus modification of GL is a perspective route in the search of new antivirals, and some of GL derivatives are potent as anti-influenza A/H1N1 agents.||URI:||https://cris.pasteurorg.ru/handle/123456789/157||ISSN:||0960-894X||DOI:||10.1016/j.bmcl.2015.02.074|
|Appears in Collections:||Journal articles|
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