Please use this identifier to cite or link to this item:
Title: Glycyrrhizic acid derivatives as influenza A/H1N1 virus inhibitors
Authors: Baltina, Lidia A
Baltina, Lia A
Orshanskaya, Iana A
Fairushina, Alina I
Kiselev, Oleg I
Yunusov, Marat S
Zarubaev, Vladimir V. 
Keywords: Analogs;Antivirals;Derivatives;Glycyrrhizic acid;Influenza A/H1N1 virus
Issue Date: 15-Apr-2015
Publisher: Elsevier
Journal: Bioorganic and Medicinal Chemistry Letters 
Abstract: This Letter describes the synthesis and antiviral activity study of some glycyrrhizic acid (GL) derivatives against influenza A/H1N1/pdm09 virus in MDCK cells. Conjugation of GL with l-amino acids or their methyl esters, and amino sugar (d-galactose amine) dramatically changed its activity. The most active compounds were GL conjugates with aromatic amino acids methyl esters (phenylalanine and tyrosine) (SI=61 and 38), and S-benzyl-cysteine (SI=71). Thus modification of GL is a perspective route in the search of new antivirals, and some of GL derivatives are potent as anti-influenza A/H1N1 agents.
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2015.02.074
Appears in Collections:Journal articles

Show full item record


checked on May 14, 2019

Page view(s)

checked on May 20, 2019

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.