Please use this identifier to cite or link to this item:
|Title:||Synthesis and anti-viral activity of azolo-adamantanes against influenza A virus||Authors:||Golod, Efim L
Anfimov, Pavel M
Shtro, Anna A
Saraev, Victor V
Gavrilov, Alexey S
Logvinov, Alexander V
Kiselev, Oleg I
Zarubaev, Vladimir V.
|Issue Date:||15-Jan-2010||Publisher:||Elsevier||Journal:||Bioorganic and Medicinal Chemistry||Abstract:||Chemotherapy and chemoprophylaxis of influenza is one of the most important directions of health protection activity. Due to the high rate of drug-resistant strains of influenza virus, there is a need for the search and further development of new potent antivirals against influenza with a broad spectrum of activity. In the present study, a set of di-, tri- and tetrazole derivatives of adamantane was efficiently prepared and their anti-influenza activities evaluated against rimantadine-resistant strain A/Puerto Rico/8/34. In general, derivatives of tetrazole possessed the highest virus-inhibiting activity. We demonstrated that several compounds of this set exhibited much higher activity than the currently used antiviral rimantadine, a compound of related structure. Moreover, we showed that these azolo-adamantanes were significantly less toxic. This study demonstrates that influenza viruses can be inhibited by adamantyl-azoles and thus have potential for developing antiviral agents with an alternate mechanism of action.||URI:||https://cris.pasteurorg.ru/handle/123456789/168||ISSN:||0968-0896||DOI:||10.1016/j.bmc.2009.11.047|
|Appears in Collections:||Journal articles|
Show full item record
checked on May 14, 2019
checked on May 20, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.