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Title: Hydrophobically modified low molecular weight chitosans as efficient and nontoxic gene delivery vectors
Authors: Zhang, Xin
Ercelen, Sebnem
Duportail, Guy
Schaub, Emmanuel
Tikhonov, Vladimir
Babak, Valery
Mély, Yves
Slita, Alexander V. 
Zarubaev, Vladimir V. 
Issue Date: May-2008
Publisher: Wiley
Journal: Journal of Gene Medicine 
Abstract: Chitosan derivatives are potential candidates for gene delivery because they are biocompatible and low toxic. However, their use has been limited by their moderate transfection efficiency and the rather large sizes of DNA complexes with high molecular weight chitosans. To circumvent these limitations, we used low molecular weight (approximately 5 kDa) chitosans grafted at 3 and 18 mol% with N-/2(3)-(dodec-2-enyl)succinoyl groups (HM-LMW-ch) that exhibit surfactant-like properties.
ISSN: 1099-498X
DOI: 10.1002/jgm.1167
Appears in Collections:Journal articles

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