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Title: Effect of 6-azacytidine on the course of experimental adenoviral infection in newborn Syrian hamsters
Authors: Zarubalev, V V
Slita, A V
Sukhinin, V P
Nosach, L N
Dyachenko, N S
Povnitsa, O Y
Zhovnovataya, V L
Alexeeva, I V
Palchikovskaya, L I
Issue Date: Feb-2007
Publisher: Maney Publishing
Journal: Journal of Chemotherapy 
Abstract: Adenoviral infection is a serious human pathology leading to respiratory, gastrointestinal and ocular disorders and epidemic outbreaks, especially in children's groups. Here we present the results from an investigation of anti- adenoviral effect of 6-azacytidine (6-AC) both in vitro and in vivo. The selectivity index of 6-AC for adenovirus type 5 in HEp-2 cells was 374, the 50% effective concentration was 0.5 mg/ml. For in vivo investigations we developed a model of disseminated adenoviral infection in newborn Syrian hamsters. The infectious virus was recovered from the liver, kidney, lungs and heart. Application of 6-AC led to a reduced period of the virus presence (7 days in the liver and 4 days in the kidney and heart) and lowered virus titers on day 3 post-inoculation (p.i.) (liver - 2.7 and 4.1, heart - 0 and 3.2, kidney - 0 and 2.4 log(10 )CPD(50)/mg tissue weight, in the presence and absence of 6-AC, respectively). Application of 6-AC to newborn Syrian hamsters led to partial destruction of their splenocytes. The results obtained suggest that 6-AC or 6-ACbased drugs with lower toxicity or applied topically may be suitable for therapy and prevention of adenoviral infection in humans.
ISSN: 1120-009X
DOI: 10.1179/joc.2007.19.1.44
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