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|Title:||[Protective activity of Ingavirin in experimental lethal influenza due to pandemic influenza virus A (H1N1)v in albino mice]||Authors:||Garshinina, A V
Kalinina, N A
Shtro, A A
Beliaevskaia, S V
Nebol'sin, V E
Kiselev, O I
Zarubaev, Vladimir V.
|Issue Date:||2010||Journal:||Antibiotiki i Khimoterapiia||Abstract:||Despite obvious success in the vaccine development and chemotherapy of influenza, it remains a poorly controlled infection leading to emergence of new pandemic variants of the virus with high morbidity and mortality. We investigated the protective activity of Ingavirin against the lethal influenza A (H1N1) 2009 virus infection on albino mice. Oral use of Ingavirin resulted in sharp decreasing of the mortality (index of protection up to 57%), slight decreasing of the infectious titer of the virus in the lungs (up to 40-fold), normalizing of the body weight dynamics and the lung tissue structure vs. the placebo-treated control. The degree of the bronchial epithelium damage was also strongly decreased. The results allow to consider Ingavirin as an effective antiviral against the current pandemic influenza virus.||URI:||https://cris.pasteurorg.ru/handle/123456789/185||ISSN:||0235-2990|
|Appears in Collections:||Journal articles|
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