Please use this identifier to cite or link to this item:
Title: [In vitro and in vivo effects of ingavirin on the ultrastructure and infectivity of influenza virus]
Authors: Beliaevskaia, S V
Sirotkin, A K
Anfimov, P M
Nebol'sin, V E
Kiselev, O I
Reĭkhart, D V
Zarubaev, Vladimir V. 
Issue Date: 2011
Journal: Voprosy virusologii 
Abstract: The aim of this investigation was to study the effect of ingavirin on the structure and properties of influenza virions forming in its presence. The infectious activity of the virus and the morphology of the virions were analyzed by titration in cell culture and electron microscopy, respectively. The use of ingavirin was shown to reduce the proportion of morphologically intact virions and to increase that of filamentous and giant particles. No defects of surface glycoproteins were observed. The effect of the drug did not depend on the chosen model of virus replication and it was similarly shown in both cultured human cells and laboratory animals. In MDCK and A549 cells and in the mouse lungs, viral infectious activity was decreased by 1-2 orders of magnitude in relation to a model. The findings suggest that Ingavirin is able to impair the processes of viral morphogenesis, which in turn leads to a reduction in the infectivity of progeny virions.
ISSN: 0507-4088
Appears in Collections:Journal articles

Show full item record


checked on May 14, 2019

Page view(s)

checked on May 20, 2019

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.