Please use this identifier to cite or link to this item: https://cris.pasteurorg.ru/handle/123456789/191
Title: [Effect of Ingavirin on the ultrastructure of the morphogenesis of adenovirus infection in vivo]
Authors: Slita, A V
Sirotkin, A K
Beliavskaia, S V
Nebol'sin, V E
Reĭkhart, D V
Kiselev, O I
Zarubaev, Vladimir V. 
Issue Date: 2012
Journal: Voprosy virusologii 
Abstract: The goal of this study was to evaluate the effect of Ingavirin on the morphological features of the foci of adenovirus hepatitis in Syrian hamsters by electron microscopy. The use of the drug was shown to cause a substantial reduction in the rate of destructive processes and inflammatory reactions in the liver, by normalizing its structure at the levels of both tissue and individual hepatocytes. After administration of Ingavirin, the morphogenesis of adenovirus infection in the infected hepatocytes did not differ from that in the controls; however, the infected cells were fewer. The proportion of morphologically inadequate virions in the presence of Ingavirin increased from 35 to 46%. The findings suggest that Ingavirin is an effective drug that has antiviral, anti-inflammatory, and cytoprotective activities in the focus of adenovirus tissue involvement.
URI: https://cris.pasteurorg.ru/handle/123456789/191
ISSN: 0507-4088
Appears in Collections:Journal articles

Show full item record

Page view(s)

1
checked on May 20, 2019

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.