Please use this identifier to cite or link to this item: https://cris.pasteurorg.ru/handle/123456789/207
Title: THE PRESENT DAY PERCEPTION OF THE PROBLEM OF IMMUNE RESTORATION OF UPON ART
Authors: Trofimova, T. N.
Boeva, E. V.
Semenova, M. D.
Belyakov, Nikolay A. 
Keywords: HIV;ART;immunity;opportunistic diseases;immune restoration syndrome
Issue Date: 1-Jun-2018
Source: Belyakov N.A., Trofimova T.N., Boeva E.V., Semenova M.D. THE PRESENT DAY PERCEPTION OF THE PROBLEM OF IMMUNE RESTORATION OF UPON ART. HIV Infection and Immunosuppressive Disorders. 2018;10(2):14-27. (In Russ.) https://doi.org/10.22328/2077-9828-2018-10-2-14-27
Project: Изучение иммуногенетических механизмов контроля прогрессирования и снижения риска передачи ВИЧ-инфекции и научное обоснование лабораторных методов исследования нового поколения для диагностики и мониторинга популяций 
Journal: HIV Infection and Immunosuppressive Disorders 
Abstract: Antiretroviral therapy (ART), which is intended to inhibit HIV replication, promotes partial restoration or activation of immunity. In many patients who have severe immunosuppression, ART may increase the risk of development of immune restoration syndrome (IRS), which is associated with the manifestations of opportunistic and secondary diseases that lead to worsening of the general health of patients and to their death. The present paper addresses IRS-related terminology, the risk factors of IRS development, and IRS pathogenesis, epidemiology, and clinical and laboratory manifestations. Special attention is paid to secondary and opportunistic infections associated with IRS and to the possibilities of pharmacotherapy for IRS and its complications. Characteristic radiological manifestations of brain lesions upon IRS are described as they as associated with different pathogenic factors upon initially poor immunity. It is hard to assess IRS incidence inRussia: IRS is diagnosed seldom becauseВИЧинфекция и иммуносупрессии,2018 г., Том 10, № 2 15 of the ambiguity of its clinical picture. A combination of the main clinical and laboratory manifestations of the syndrome is suggested to help in IRS diagnosis. IRS prevention is based on reasonable regiments of ART following preventing therapy for possible manifested infections and also on early ART onset upon steady CD4 cell counts and low HIV RNA blood levels.
URI: https://cris.pasteurorg.ru/handle/123456789/207
ISSN: 2077-9828
DOI: 10.22328/2077-9828-2018-10-2-14-27
Appears in Collections:Journal articles

Show full item record

Page view(s)

1
checked on May 20, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.