Please use this identifier to cite or link to this item:
|Title:||[The detection of antibodies to HCV F protein with immune enzyme analysis using synthetic peptide.]||Authors:||Klimashevskaya, S V
Obryadina, A P
Belopolskaya, M A
Lichnaia, Evgeniia V.
Verbov, Vyacheslav N.
Esaulenko, Elena V.
Kalinina, Olga V.
|Keywords:||chronic hepatitis C;enzyme-linked immunosorbent assay;hepatitis C virus;protein F||Issue Date:||1-Mar-2018||Publisher:||Meditsina Moscow||Project:||Изучение современных особенностей эпидемического процесса вирусных гепатитов.||Journal:||Klinicheskaia Laboratornaia Diagnostika||Abstract:||Alternative reading frame encoding a single protein known as protein F or core + 1 / ARFP is located in the core region of the hepatitis C virus (HCV) genome. The presence of antibodies to the F protein of HCV in the serum of patients with chronic hepatitis C indicates the expression of this protein in vivo. In this study, to determine antibodies to the F protein of HCV in serum samples the methodology of the enzyme immunoassay (ELISA) was developed using the synthetic peptide F10 corresponding to the antigenic determinant of the F protein of the HCV subtype 1b. The immunogenicity and immunochemical specificity of synthetic F10 peptide has been demonstrated in laboratory animals (mice).||URI:||https://cris.pasteurorg.ru/handle/123456789/211||ISSN:||0869-2084||DOI:||10.18821/0869-2084-2018-63-3-183-186|
|Appears in Collections:||Journal articles|
Show full item record
checked on May 20, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.