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Title: [The detection of antibodies to HCV F protein with immune enzyme analysis using synthetic peptide.]
Authors: Klimashevskaya, S V
Obryadina, A P
Belopolskaya, M A
Lichnaia, Evgeniia V. 
Verbov, Vyacheslav N. 
Esaulenko, Elena V. 
Kalinina, Olga V. 
Keywords: chronic hepatitis C;enzyme-linked immunosorbent assay;hepatitis C virus;protein F
Issue Date: 1-Mar-2018
Publisher: Meditsina Moscow
Project: Изучение современных особенностей эпидемического процесса вирусных гепатитов. 
Journal: Klinicheskaia Laboratornaia Diagnostika 
Abstract: Alternative reading frame encoding a single protein known as protein F or core + 1 / ARFP is located in the core region of the hepatitis C virus (HCV) genome. The presence of antibodies to the F protein of HCV in the serum of patients with chronic hepatitis C indicates the expression of this protein in vivo. In this study, to determine antibodies to the F protein of HCV in serum samples the methodology of the enzyme immunoassay (ELISA) was developed using the synthetic peptide F10 corresponding to the antigenic determinant of the F protein of the HCV subtype 1b. The immunogenicity and immunochemical specificity of synthetic F10 peptide has been demonstrated in laboratory animals (mice).
ISSN: 0869-2084
DOI: 10.18821/0869-2084-2018-63-3-183-186
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