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Title: Synthesis of d-(+)-camphor-based N-acylhydrazones and their antiviral activity
Authors: Kovaleva, Kseniya S
Zubkov, Fedor I
Bormotov, Nikolay I
Novikov, Roman A
Dorovatovskii, Pavel V
Khrustalev, Victor N
Gatilov, Yuriy V
Yarovaya, Olga I
Shishkina, Larisa N
Salakhutdinov, Nariman F
Zarubaev, Vladimir V. 
Issue Date: 1-Dec-2018
Publisher: Royal Society of Chemistry
Journal: MedChemComm 
Abstract: The design and synthesis of a series of novel d-(+)-camphor N-acylhydrazones exhibiting inhibitory activity against vaccinia and influenza viruses are presented. An easy pathway to camphor-based N-acylhydrazones containing in their structure aliphatic, aromatic, and heterocyclic pharmacophore scaffolds has been developed. The conformation and configuration of the synthesized hydrazones were thoroughly characterized by a complete set of spectral characterization techniques, including 2D NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis. In vitro screening for activity against vaccinia virus (VV) and influenza H1N1 virus was carried out for the obtained compounds. It was revealed that the derived N-acylhydrazones exhibited significant antiviral activity with a selectivity index >280 against VV for the most promising compound.
ISSN: 2040-2503
DOI: 10.1039/c8md00442k
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