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|Title:||New epidemic cluster of pre-extensively drug resistant isolates of Mycobacterium tuberculosis Ural family emerging in Eastern Europe||Authors:||Sinkov, Viacheslav
Heysell, Scott K
Mokrousov, Igor V.
|Keywords:||Molecular epidemiology;Molecular evolution;Mycobacterium tuberculosis;Next generation sequencing;Phylogenetics;Phylogeography;Population genetics;Ural genotype||Issue Date:||22-Oct-2018||Publisher:||BMC||Journal:||BMC Genomics||Abstract:||Ural genetic family is a part of the Euro-American lineage of Mycobacterium tuberculosis and is endemic in Northern Eurasia (former Soviet Union [FSU]). These strains were long described as drug susceptible and of low virulence, but recent studies reported an increasing circulation of the multidrug-resistant (MDR) and extensively drug-resistant (XDR) Ural strains. Here, we analyzed all publicly available whole genome sequence data of Ural genotype isolates, in order to elucidate their phylogenomic diversity with a special focus on MDR and potentially epidemic clones.||URI:||https://cris.pasteurorg.ru/handle/123456789/39||ISSN:||1471-2164||DOI:||10.1186/s12864-018-5162-3|
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