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Title: New epidemic cluster of pre-extensively drug resistant isolates of Mycobacterium tuberculosis Ural family emerging in Eastern Europe
Authors: Sinkov, Viacheslav
Ogarkov, Oleg
Bukin, Yuri
Zhdanova, Svetlana
Heysell, Scott K
Mokrousov, Igor V. 
Keywords: Molecular epidemiology;Molecular evolution;Mycobacterium tuberculosis;Next generation sequencing;Phylogenetics;Phylogeography;Population genetics;Ural genotype
Issue Date: 22-Oct-2018
Publisher: BMC
Journal: BMC Genomics 
Abstract: Ural genetic family is a part of the Euro-American lineage of Mycobacterium tuberculosis and is endemic in Northern Eurasia (former Soviet Union [FSU]). These strains were long described as drug susceptible and of low virulence, but recent studies reported an increasing circulation of the multidrug-resistant (MDR) and extensively drug-resistant (XDR) Ural strains. Here, we analyzed all publicly available whole genome sequence data of Ural genotype isolates, in order to elucidate their phylogenomic diversity with a special focus on MDR and potentially epidemic clones.
ISSN: 1471-2164
DOI: 10.1186/s12864-018-5162-3
Appears in Collections:Journal articles

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