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Title: Rapid Assay for Detection of the Epidemiologically Important Central Asian/Russian Strain of the Mycobacterium tuberculosis Beijing Genotype
Authors: Chernyaeva, Ekaterina
Skiba, Yuriy
Solovieva, Natalia
Valcheva, Violeta
Levina, Klavdia
Malakhova, Natalya
Jiao, Wei-Wei
Gomes, Lia Lima
Suffys, Philip N
Kütt, Marge
Aitkhozhina, Nagima
Shen, A-Dong
Zhuravlev, Viacheslav
Mokrousov, Igor V. 
Vyazovaya, Anna A. 
Narvskaya, Olga V. 
Keywords: Beijing genotype;Central Asian outbreak;Mycobacterium tuberculosis;whole-genome sequencing
Issue Date: Feb-2018
Publisher: American Society for Microbiology
Journal: Journal of Clinical Microbiology 
Abstract: We developed an assay for rapid detection of isolates of the epidemiologically important Central Asian/Russian Beijing strain (94-32 cluster) that may serve for prospective screening and for retrospective assessment of large collections when comprehensive and time-consuming tools, such as multilocus VNTR and WGS, are not available or practical. The test to detect Central Asian/Russian Beijing 94-32 cluster isolates developed presently may be used in parallel with a previously developed test to detect isolates of the Beijing B0/W148 cluster termed “successful Russian clone” (13) on strains identified as of the Beijing genotype. The combined use of these PCR-based assays will permit a rapid (1-day) detection of both the major and the epidemic clonal clusters of M. tuberculosis circulating in the countries of the Former Soviet Union and being spread by immigrants to different parts of the world.
ISSN: 0095-1137
DOI: 10.1128/JCM.01551-17
Appears in Collections:Journal articles

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