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|Title:||Emerging peak on the phylogeographic landscape of Mycobacterium tuberculosis in West Asia: Definitely smoke, likely fire||Authors:||Shitikov, Egor
Mokrousov, Igor V.
Vyazovaya, Anna A.
|Keywords:||Euro-American superlineage;Mycobacterium tuberculosis;Next generation sequencing;Phylogeny;Phylogeography;Whole genome sequencing||Issue Date:||Nov-2017||Publisher:||Elsevier||Journal:||Molecular Phylogenetics and Evolution||Abstract:||To date, a major attention was justly given to the global lineages of Mycobacterium tuberculosis. Here, we demonstrated an importance of the minor ones, on an example of intriguing and underestimated NEW-1 family that belongs to Euro-American lineage (lineage 4). Analysis of the global WGS/NGS datasets (5715 strains) identified 2235 strains of Lineage 4 and 66 strains of sublineage L4.5. This latter is marked with RD122 genomic deletion and includes NEW-1 family. Phylogenomic analysis confirmed a separate position of the NEW-1 family that we tentatively designate L4.5.1/Iran. We propose an evolution/migration scenario starting with origin of L4.5 1000-1300 ya in China, subsequent origin of the pre-NEW-1 intermediate genotype in Tibet, further migration to Xinjiang/Uyghur, and finally to Iran since 800 ya (origin of NEW-1), possibly, via expansion of the Mongol Yuan empire. Analysis of longitudinal phylogeographic datasets revealed a sharp increase in prevalence of NEW-1 strains in Iran and its eastwards neighbors in the last 20years; most alarmingly, it is accompanied with significant association with multidrug resistance (MDR). Ongoing migration, especially, Afghan refugees flows to developed countries emphasize a risk of the wider spread of the epidemic MDR subtype within NEW-1 family that we coin as emerging resistant clone of M. tuberculosis in West Asia.||URI:||https://cris.pasteurorg.ru/handle/123456789/62||ISSN:||1055-7903||DOI:||10.1016/j.ympev.2017.09.002|
|Appears in Collections:||Journal articles|
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