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|Title:||Revisiting the Hunter Gaston discriminatory index: Note of caution and courses of change||Authors:||Mokrousov, Igor V.||Keywords:||Discriminatory power;Hunter Gaston index;Molecular typing;Shannon-Wiener index;Spoligotyping;VNTR||Issue Date:||May-2017||Publisher:||Elsevier||Journal:||Tuberculosis||Abstract:||Hunter Gaston Discriminatory Index (HGDI) is a widely used estimator of discriminatory power of genotyping methods and diversity of molecular markers in bacterial pathogens, including Mycobacterium tuberculosis. In my opinion, the index is somewhat misleading: a closer look at common practice and particular studies reveals that values in the range of 0.6-0.9 are modest but uncritically perceived as high. I propose and discuss three courses of change: (i) to continue using HGDI but be aware of the true meaning behind its value and increase a threshold of acceptable resolution to the more adequate values of 0.90-0.99, depending on study design; (ii) to turn to other known indices of diversity (e.g., Shannon index), in order to complement HGDI; (iii) to develop new, intuitively more realistic estimator.||URI:||https://cris.pasteurorg.ru/handle/123456789/66||ISSN:||1472-9792||DOI:||10.1016/j.tube.2017.02.002|
|Appears in Collections:||Journal articles|
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