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Title: Trends in molecular epidemiology of drug-resistant tuberculosis in Republic of Karelia, Russian Federation
Authors: Solovieva, Natalia
Sunchalina, Tatiana
Markelov, Yuri
Chernyaeva, Ekaterina
Melnikova, Natalia
Dogonadze, Marine
Vasilieva, Neliya
Kononenko, Yulia
Zhuravlev, Viacheslav
Mokrousov, Igor V. 
Vyazovaya, Anna A. 
Starkova, Daria A. 
Gerasimova, Alena A. 
Narvskaya, Olga V. 
Issue Date: 18-Dec-2015
Publisher: BMC
Journal: BMC Microbiology 
Abstract: Russian Republic of Karelia is located at the Russian-Finnish border. It contains most of the historical Karelia land inhabited with autochthonous Karels and more recently migrated Russians. Although tuberculosis (TB) incidence in Karelia is decreasing, it remains high (45.8/100 000 in 2014) with the rate of multi-drug resistance (MDR) among newly diagnosed TB patients reaching 46.5 %. The study aimed to genetically characterize Mycobacterium tuberculosis isolates obtained at different time points from TB patients from Karelia to gain insight into the phylogeographic specificity of the circulating genotypes and to assess trends in evolution of drug resistant subpopulations.
ISSN: 1471-2180
DOI: 10.1186/s12866-015-0613-3
Appears in Collections:Journal articles

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