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Title: Synthesis of some CC chemokines and their receptors in the synovium in rheumatoid arthritis
Authors: Zhebrun, D A 
Totolian, Areg A 
Maslyanskii, A L 
Titov, A G 
Patrukhin, A P 
Kostareva, A A 
Gol'tseva, I S 
Issue Date: Dec-2014
Publisher: Springer Verlag
Journal: Bulletin of Experimental Biology and Medicine 
Abstract: We studied the expression of some CC chemokines and their receptors in the synovium of patients with rheumatoid arthritis, osteoarthrosis, and a history of joint injury. In patients with rheumatoid arthritis, the levels mRNA for some angiogenic and proinflammatory chemokines (CCL5/RANTES, CCL11/eotaxin, CCL24/eotaxin-2, and CCL26/eotaxin-3) and their receptors (CCR1, CCR2, CCR3, CCR4, and CCR5) was elevated. mRNA expression correlated with activity, stage, and serological status of rheumatoid arthritis. Obtained data confirm the importance of CC chemokines as mediators of angiogenesis and inflammation in the synovium in rheumatoid arthritis.
ISSN: 0007-4888
DOI: 10.1007/s10517-014-2720-9
Appears in Collections:Cтатьи в журналах/Journal articles

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