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Title: Revisiting the Hunter Gaston discriminatory index: Note of caution and courses of change
Authors: Mokrousov, Igor V 
Keywords: Discriminatory power;Hunter Gaston index;Molecular typing;Shannon-Wiener index;Spoligotyping;VNTR
Issue Date: May-2017
Publisher: Elsevier
Journal: Tuberculosis 
Abstract: Hunter Gaston Discriminatory Index (HGDI) is a widely used estimator of discriminatory power of genotyping methods and diversity of molecular markers in bacterial pathogens, including Mycobacterium tuberculosis. In my opinion, the index is somewhat misleading: a closer look at common practice and particular studies reveals that values in the range of 0.6-0.9 are modest but uncritically perceived as high. I propose and discuss three courses of change: (i) to continue using HGDI but be aware of the true meaning behind its value and increase a threshold of acceptable resolution to the more adequate values of 0.90-0.99, depending on study design; (ii) to turn to other known indices of diversity (e.g., Shannon index), in order to complement HGDI; (iii) to develop new, intuitively more realistic estimator.
ISSN: 1472-9792
DOI: 10.1016/
Appears in Collections:Cтатьи в журналах/Journal articles

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