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Title: Real-time PCR assay for rapid detection of epidemiologically and clinically significant Mycobacterium tuberculosis Beijing genotype isolates
Authors: Zhuravlev, Viacheslav
Otten, Tatiana
Millet, Julie
Jiao, Wei-Wei
Shen, A-Dong
Rastogi, Nalin
Vishnevsky, Boris
Mokrousov, Igor V. 
Vyazovaya, Anna A. 
Narvskaya, Olga V. 
Issue Date: May-2014
Publisher: American Society for Microbiology
Journal: Journal of Clinical Microbiology 
Abstract: Mycobacterium tuberculosis Beijing genotype strains are rapidly disseminating, frequently hypervirulent, and multidrug resistant. Here, we describe a method for their rapid detection by real-time PCR that targets the specific IS6110 insertion in the dnaA-dnaN genome region. The method was evaluated with a geographically and genetically diverse collection representing areas in East Asia and the former Soviet Union in which the Beijing genotype is endemic and epidemic (i.e., major foci of its global propagation) and with clinical specimens.
ISSN: 0095-1137
DOI: 10.1128/JCM.03193-13
Appears in Collections:Journal articles

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